Ontology highlight
ABSTRACT:
SUBMITTER: Murugan RN
PROVIDER: S-EPMC3887635 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Murugan Ravichandran N RN Park Jung-Eun JE Kim Eun-Hee EH Shin Song Yub SY Cheong Chaejoon C Lee Kyung S KS Bang Jeong Kyu JK
Molecules and cells 20110729 3
Members of polo-like kinases (collectively, Plks) have been identified in various eukaryotic organisms and play pivotal roles in cell proliferation. They are characterized by the presence of a distinct region of homology in the C-terminal noncatalytic domain, called polo-box domain (PBD). Among them, Plk1 and its functional homologs in other organisms have been best characterized because of its strong association with tumorigenesis. Plk1 is overexpressed in a wide spectrum of cancers in humans, ...[more]