Ontology highlight
ABSTRACT:
SUBMITTER: Chang S
PROVIDER: S-EPMC3887789 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Chang Suhwan S Sharan Shyam K SK
Molecules and cells 20120724 5
BRCA1 is a well-known tumor suppressor implicated in familial breast and ovarian cancer. Since its cloning in 1994, numerous studies have established BRCA1's role in diverse cellular and biochemical processes, such as DNA damage repair, cell cycle control, and transcriptional regulation as well as ubiquitination. In addition, a number of recent studies have functionally linked this tumor suppressor to another important cellular regulator, microRNAs, which are short (19-22 nt) RNAs that were disc ...[more]