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Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis.


ABSTRACT:

Background

Current recommendations for the management of axial spondyloarthritis (SpA) and psoriatic arthritis are to monitor disease activity and adjust therapy accordingly. However, treatment targets and timeframes of change have not been defined. An international expert panel has been convened to develop 'treat-to-target' recommendations, based on published evidence and expert opinion.

Objective

To review evidence on targeted treatment for axial and peripheral SpA, as well as for psoriatic skin disease.

Methods

We performed a systematic literature search covering Medline, Embase and Cochrane, conference abstracts and studies in http://www.clinicaltrials.gov.

Results

Randomised comparisons of targeted versus routine treatment are lacking. Some studies implemented treatment targets before escalating therapy: in ankylosing spondylitis, most trials used a decrease in Bath Ankylosing Spondylitis Disease Activity Index; in psoriatic arthritis, protocols primarily considered a reduction in swollen and tender joints; in psoriasis, the Modified Psoriasis Severity Score and the Psoriasis Area and Severity Index were used. Complementary evidence correlating these factors with function and radiographic damage at follow-up is sparse and equivocal.

Conclusions

There is a need for randomised trials that investigate the value of treat-to-target recommendations in SpA and psoriasis. Several trials have used thresholds of disease activity measures to guide treatment decisions. However, evidence on the effect of these data on long-term outcome is scarce. The search data informed the expert committee regarding the formulation of recommendations and a research agenda.

SUBMITTER: Schoels MM 

PROVIDER: S-EPMC3888585 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Publications

Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis.

Schoels M M MM   Braun J J   Dougados M M   Emery P P   Fitzgerald O O   Kavanaugh A A   Kvien T K TK   Landewé R R   Luger T T   Mease P P   Olivieri I I   Reveille J J   Ritchlin C C   Rudwaleit M M   Sieper J J   Smolen J S JS   Wit M de Md   van der Heijde D D  

Annals of the rheumatic diseases 20130605 1


<h4>Background</h4>Current recommendations for the management of axial spondyloarthritis (SpA) and psoriatic arthritis are to monitor disease activity and adjust therapy accordingly. However, treatment targets and timeframes of change have not been defined. An international expert panel has been convened to develop 'treat-to-target' recommendations, based on published evidence and expert opinion.<h4>Objective</h4>To review evidence on targeted treatment for axial and peripheral SpA, as well as f  ...[more]

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