Ontology highlight
ABSTRACT:
SUBMITTER: Chillakuri CR
PROVIDER: S-EPMC3888931 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Chillakuri Chandramouli R CR Sheppard Devon D Ilagan Ma Xenia G MX Holt Laurie R LR Abbott Felicity F Liang Shaoyan S Kopan Raphael R Handford Penny A PA Lea Susan M SM
Cell reports 20131114 4
The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. Signals are initiated by extracellular interactions of the Notch receptor with Delta/Serrate/Lag-2 (DSL) ligands, whose structure is highly conserved throughout evolution. To date, no structure or activity has been associated with the extreme N termini of the ligands, even though numerous mutations in this regio ...[more]