Ontology highlight
ABSTRACT:
SUBMITTER: Marzec M
PROVIDER: S-EPMC3889215 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Marzec Michal M Halasa Krzysztof K Liu Xiaobin X Wang Hong Y HY Cheng Mangeng M Baldwin Donald D Tobias John W JW Schuster Stephen J SJ Woetmann Anders A Zhang Qian Q Turner Suzanne D SD Ødum Niels N Wasik Mariusz A MA
Journal of immunology (Baltimore, Md. : 1950) 20131111 12
Anaplastic lymphoma kinase (ALK), physiologically expressed only by nervous system cells, displays a remarkable capacity to transform CD4(+) T lymphocytes and other types of nonneural cells. In this study, we report that activity of nucleophosmin (NPM)/ALK chimeric protein, the dominant form of ALK expressed in T cell lymphomas (TCLs), closely resembles cell activation induced by IL-2, the key cytokine supporting growth and survival of normal CD4(+) T lymphocytes. Direct comparison of gene expre ...[more]