Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors.
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ABSTRACT:
SUBMITTER: Rudick JG
PROVIDER: S-EPMC3889485 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors.
Rudick Jonathan G JG Laakso Meg M MM Schloss Ashley C AC DeGrado William F WF
Organic & biomolecular chemistry 20131101 41
Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO3DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified. ...[more]
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