Ontology highlight
ABSTRACT:
SUBMITTER: Savolainen L
PROVIDER: S-EPMC3889579 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Savolainen Laura L Kantele Anu A Sandboge Bettina B Sirén Marita M Valleala Heikki H Tuompo Riitta R Pusa Liana L Erkinjuntti-Pekkanen Riitta R Knuuttila Aija A Ku Cheng-Lung CL Chi Chih-Yu CY Vasankari Tuula T Tuuminen Tamara T
Clinical and vaccine immunology : CVI 20130703 9
Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-fold allowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA) from 7% to 57% yet impaired its specificity from 97% to 89%. (This study has been registered at Univer ...[more]