Ontology highlight
ABSTRACT:
SUBMITTER: Ali SR
PROVIDER: S-EPMC3889666 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Immunity 20110616 1
Detection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to activation of protective host responses. However, it is still unclear how immune cells specifically respond to pathogenic bacteria. Using virulent and nonvirulent strains of Bacillus anthracis, we have shown that secretion of ATP by infected macrophages and the sequential activation of the P2X7 purinergic receptor and nucleotide binding oligomeriz ...[more]