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Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs.

ABSTRACT: Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic lesions by 2.4-fold (P < 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.

SUBMITTER: Wang Y

PROVIDER: S-EPMC3890236 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs.

Wang Yian Y Zhang Zhongqiu Z Garbow Joel R JR Rowland Doug J DJ Lubet Ronald A RA Sit Daniel D Law Francis F You Ming M

Cancer prevention research (Philadelphia, Pa.) 20090701 7

Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic le ...[more]

PMID: 19584077

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