Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.
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ABSTRACT:
SUBMITTER: Perez LJ
PROVIDER: S-EPMC3890260 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Highly Potent, Chemically Stable Quorum Sensing Agonists for <i>Vibrio Cholerae.</i>
Perez Lark J LJ Karagounis Theodora K TK Hurley Amanda A Bassler Bonnie L BL Semmelhack Martin F MF
Chemical science 20140101 1
In the <i>Vibrio cholerae</i> pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of <i>V. cholerae</i> quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in <i>V. cholerae</i>. ...[more]
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