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Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis.

ABSTRACT: Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

SUBMITTER: Hoffman LR

PROVIDER: S-EPMC3890337 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis.

Hoffman Lucas R LR Pope Christopher E CE Hayden Hillary S HS Heltshe Sonya S Levy Roie R McNamara Sharon S Jacobs Michael A MA Rohmer Laurence L Radey Matthew M Ramsey Bonnie W BW Brittnacher Mitchell J MJ Borenstein Elhanan E Miller Samuel I SI

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20131030 3

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction. ...[more]

PMID: 24178246

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Metagenomic evidence for taxonomic dysbiosis and functional imbalance in the gastrointestinal tracts of children with cystic fibrosis.

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Project description:Early microbiota dysbiosis and intestinal inflammation in children with cystic fibrosis

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