Ontology highlight
ABSTRACT:
SUBMITTER: Davoli T
PROVIDER: S-EPMC3891052 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Davoli Teresa T Xu Andrew Wei AW Mengwasser Kristen E KE Sack Laura M LM Yoon John C JC Park Peter J PJ Elledge Stephen J SJ
Cell 20131031 4
Aneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here, we develop Tumor Suppressor and Oncogene (TUSON) Explorer, a computational method that analyzes the patterns of mutational signatures in tumors and predicts the likelihood that any individual gene functions as a tumor suppressor (TSG) or oncogene (OG). By analyzing >8,200 tumor-normal pairs, we provide statistical evide ...[more]