Dataset Information

Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.

ABSTRACT:

Objective

Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinary aldosterone level, plasma renin activity and aldosterone-to-renin ratio on this task.

Methods

We performed echocardiography in 106 patients with PA and 31 subjects with essential hypertension (EH) in a tertiary teaching hospital. Plasma renin activity, aldosterone concentration, and 24-hour urinary aldosterone level were measured.

Results

Only 24-hour urinary aldosterone was correlated with left ventricular mass index (LVMI) and excess LVMI among these parameters. The multivariate analysis revealed the urinary aldosterone level as an independent predictor for LVMI and excess LVMI. Analyzing the ability of urinary aldosterone, plasma aldosterone concentration, and plasma aldosterone-to-renin ratio to identify the presence of LVH (ROC AUC?=?0.701, 0.568, 0.656, resp.) and the presence of inappropriate LV mass index (defined as measured LVMI in predicting LVMI ratio >135%) (ROC area under curve = 0.61, 0.43, 0.493, resp.) revealed the better performance of 24-hour urinary aldosterone.

Conclusions

In conclusion, 24-hour urinary aldosterone level performed better to predict the presence of LVH and inappropriate LVMI in patients with PA.

SUBMITTER: Hung CS

PROVIDER: S-EPMC3891226 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.

Hung Chi-Sheng CS Ho Yi-Lwun YL Chang Yi-Yao YY Wu Vin-Cent VC Wu Xue-Ming XM Lee Jen-Kuang JK Chueh Shih-Chieh SC Lin Yen-Hung YH Changh Yuan-Shian YS Yang Shao-Yu SY Hu Ya-Hui YH Sui Ming-Jai MJ Chen Ming-Fong MF Wu Kwan-Dun KD

TheScientificWorldJournal 20131229

<h4>Objective</h4>Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinary aldosterone level, plasma renin activity and aldosterone-to-renin ratio on this task.<h4>Methods</h4>We performed echocardiography in 106 patients with PA and 31 subjects with essential hyper ...[more]

PMID: 24459427

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Dataset Information

Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.

Objective

Methods

Results

Conclusions

Publications

Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.

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