Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.
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ABSTRACT:
SUBMITTER: Metcalf CJ
PROVIDER: S-EPMC3891600 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.
Metcalf C J E CJ Graham A L AL Huijben S S Barclay V C VC Long G H GH Grenfell B T BT Read A F AF Bjørnstad O N ON
Science (New York, N.Y.) 20110801 6045
Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease severity and transmission. Quantitatively partitioning the relative roles of these effects through time is challenging. Using data from rodent malaria, we estimated the effective propagation number, which reflects the relative importance of contrasting within-host control mechanisms through time and is sensitive to the inoculating parasite dose. ...[more]
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