Ontology highlight
ABSTRACT:
SUBMITTER: Heger K
PROVIDER: S-EPMC3891641 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
PLoS biology 20140114 1
Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient mice is controversial. We therefore established an in vivo model for hyperactive mast cells by specifically ablating the NF-κB negative feedback regulator A20. While A20 deficiency did not affect mast cell degranulation, it resulted in amplified pro-inflammatory responses downstream of IgE/FcεRI, TLRs, IL-1R, and IL-33R. As a consequence house dust m ...[more]