Unknown

Dataset Information

0

Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.

ABSTRACT: A neurofibromatosis type 1 (NF1) based bioassay-guided phytochemical investigation on Simarouba berteroana led to the isolation of one new canthin-6-one-9-methoxy-5-O-?-D-glucopyranoside (1), seven known canthine alkaloids (2-8), two known quassinoids (9-10) and a known neo-lignan (11). The structures of all compounds were established by HRMS, 1D- and 2D-NMR analysis and comparison with previously reported data. Most of the compounds inhibited the proliferation of an Nf1- and p53-deficient mouse glioma cell line at non-cytotoxic concentrations.

SUBMITTER: Devkota KP 

PROVIDER: S-EPMC3891785 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Compounds from <i>Simarouba berteroana</i> which inhibit proliferation of <i>NF1</i>-defective cancer cells.

Devkota Krishna P KP   Wilson Jennifer A JA   Henrich Curtis J CJ   McMahon James B JB   Reilly Karlyne M KM   Beutler John A JA  

Phytochemistry letters 20140201

A neurofibromatosis type 1 (<i>NF1</i>) based bioassay-guided phytochemical investigation on <i>Simarouba berteroana</i> led to the isolation of one new canthin-6-one-9-methoxy-5-<i>O</i>-<i>β</i>-<i>D</i>-glucopyranoside (<b>1</b>), seven known canthine alkaloids (<b>2</b>-<b>8</b>), two known quassinoids (<b>9</b>-<b>10</b>) and a known neo-lignan (<b>11</b>). The structures of all compounds were established by HRMS, 1D- and 2D-NMR analysis and comparison with previously reported data. Most of  ...[more]

Similar Datasets

Unknown Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.
| S-EPMC3556213 | biostudies-literature
Unknown Novel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway.
| S-EPMC7180728 | biostudies-literature
Unknown Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation.
| S-EPMC9124600 | biostudies-literature
Unknown Ultrasound-Activated Piezoelectric Nanoparticles Inhibit Proliferation of Breast Cancer Cells.
| S-EPMC5908835 | biostudies-other
Unknown Sulfur-containing histidine compounds inhibit γ-glutamyl transpeptidase activity in human cancer cells.
| S-EPMC6779435 | biostudies-literature
Unknown M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells.
| S-EPMC4622460 | biostudies-literature
Unknown Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice.
| S-EPMC6413339 | biostudies-literature
Unknown Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.
| S-EPMC4171615 | biostudies-literature
Unknown Proton Beams Inhibit Proliferation of Breast Cancer Cells by Altering DNA Methylation Status.
| S-EPMC4747889 | biostudies-literature
Unknown Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines.
| S-EPMC5133839 | biostudies-other