Ontology highlight
ABSTRACT:
SUBMITTER: Zhao D
PROVIDER: S-EPMC3891909 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Zhao Dongchang D Young James S JS Chen Yu-Hong YH Shen Elizabeth E Yi Tangsheng T Todorov Ivan I Chu Peiguo G PG Forman Stephen J SJ Zeng Defu D
Journal of immunology (Baltimore, Md. : 1950) 20101213 2
Chronic graft-versus-host disease (cGVHD) is considered an autoimmune-like disease mediated by donor CD4(+) T cells, but the origin of the autoreactive T cells is still controversial. In this article, we report that the transplantation of DBA/2 donor spleen cells into thymectomized MHC-matched allogeneic BALB/c recipients induced autoimmune-like cGVHD, although not in control syngeneic DBA/2 recipients. The donor-type CD4(+) T cells from the former but not the latter recipients induced autoimmun ...[more]