Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3891913 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Li Xiaofan X Deng Ruishu R He Wei W Liu Can C Wang Miao M Young James J Meng Zhipeng Z Du Chantal C Huang Wendong W Chen Lieping L Chen Yuanzhong Y Martin Paul P Forman Stephen S Zeng Defu D
Journal of immunology (Baltimore, Md. : 1950) 20111212 2
Previous experimental studies have shown that acute graft-versus-host disease (GVHD) is associated with two waves of donor CD8(+) T cell expansion. In the current studies, we used in vivo bioluminescent imaging, in vivo BrdU labeling, and three different experimental GVHD systems to show that B7-H1 expression by recipient parenchymal cells controls the second wave of alloreactive donor CD8(+) T cell expansion and the associated second phase of GVHD. Loss of B7-H1 expression by parenchymal cells ...[more]