Differentially expressed microRNAs in the serum of cervical squamous cell carcinoma patients before and after surgery.

ABSTRACT:

Background

The purpose of this study was to detect the serum microRNAs (miRNAs) that are differentially expressed in cervical squamous cell carcinoma (SCC) patients and negative controls, with a focus on the miRNA profiles of the patients before and after surgery. The aim of the study is to evaluate the potential of these miRNAs as novel markers for the post-therapeutic monitoring of cervical SCC patients.

Results

A total of 765 serum miRNAs from 10 cervical SCC patients before surgery, 10 cervical SCC patients after surgery, and 10 negative controls were profiled using a TaqMan MicroRNA Array. A set of selected differentially expressed miRNAs were further analyzed in the patients at different perioperative periods, including preoperative, 1 week postoperative, and one month

SUBMITTER: Wang WT 

PROVIDER: S-EPMC3892020 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature