Ontology highlight
ABSTRACT:
SUBMITTER: Davda D
PROVIDER: S-EPMC3892994 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Davda Dahvid D El Azzouny Mahmoud A MA Tom Christopher T M B CT Hernandez Jeannie L JL Majmudar Jaimeen D JD Kennedy Robert T RT Martin Brent R BR
ACS chemical biology 20130725 9
2-Bromohexadecanoic acid, or 2-bromopalmitate, was introduced nearly 50 years ago as a nonselective inhibitor of lipid metabolism. More recently, 2-bromopalmitate re-emerged as a general inhibitor of protein S-palmitoylation. Here, we investigate the cellular targets of 2-bromopalmitate through the synthesis and application of click-enabled analogues. In cells, 2-bromopalmitate is converted to 2-bromopalmitoyl-CoA, although less efficiently than free palmitate. Once conjugated to CoA, probe reac ...[more]