New advances in the genetic basis of atrial fibrillation.
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ABSTRACT:
SUBMITTER: Mahida S
PROVIDER: S-EPMC3894120 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
New advances in the genetic basis of atrial fibrillation.
Mahida Saagar S Ellinor Patrick T PT
Journal of cardiovascular electrophysiology 20121015 12
Over the past decade, compelling evidence has emerged from population-based studies to suggest that AF is a heritable disease. More recently, we have begun to elucidate the genetic substrate underlying AF. Genome-wide association studies (GWAS) have led to the identification of multiple risk loci that confer increased susceptibility to the arrhythmia. These loci harbor intriguing candidate genes including those encoding ion channels, transcription factors, and signaling molecules. Current effort ...[more]
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