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A bioreducible linear poly(?-amino ester) for siRNA delivery.

ABSTRACT: Described here is the synthesis and characterization of a novel, bioreducible linear poly(?-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

SUBMITTER: Kozielski KL 

PROVIDER: S-EPMC3894248 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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A bioreducible linear poly(β-amino ester) for siRNA delivery.

Kozielski Kristen L KL   Tzeng Stephany Y SY   Green Jordan J JJ  

Chemical communications (Cambridge, England) 20130601 46

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity. ...[more]

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