A bioreducible linear poly(?-amino ester) for siRNA delivery.
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ABSTRACT:
SUBMITTER: Kozielski KL
PROVIDER: S-EPMC3894248 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
A bioreducible linear poly(β-amino ester) for siRNA delivery.
Kozielski Kristen L KL Tzeng Stephany Y SY Green Jordan J JJ
Chemical communications (Cambridge, England) 20130601 46
Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity. ...[more]
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