A stochastic model dissects cell states in biological transition processes.
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ABSTRACT:
SUBMITTER: Armond JW
PROVIDER: S-EPMC3894565 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
A stochastic model dissects cell states in biological transition processes.
Armond Jonathan W JW Saha Krishanu K Rana Anas A AA Oates Chris J CJ Jaenisch Rudolf R Nicodemi Mario M Mukherjee Sach S
Scientific reports 20140117
Many biological processes, including differentiation, reprogramming, and disease transformations, involve transitions of cells through distinct states. Direct, unbiased investigation of cell states and their transitions is challenging due to several factors, including limitations of single-cell assays. Here we present a stochastic model of cellular transitions that allows underlying single-cell information, including cell-state-specific parameters and rates governing transitions between states, ...[more]
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