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Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

ABSTRACT: The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg(2+)) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg(2+) causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg(2+) and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg(2+) in eukaryotic cells.

SUBMITTER: Chaigne-Delalande B

PROVIDER: S-EPMC3894782 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

Chaigne-Delalande Benjamin B Li Feng-Yen FY O'Connor Geraldine M GM Lukacs Marshall J MJ Jiang Ping P Zheng Lixin L Shatzer Amber A Biancalana Matthew M Pittaluga Stefania S Matthews Helen F HF Jancel Timothy J TJ Bleesing Jack J JJ Marsh Rebecca A RA Kuijpers Taco W TW Nichols Kim E KE Lucas Carrie L CL Nagpal Sunil S Mehmet Huseyin H Su Helen C HC Cohen Jeffrey I JI Uzel Gulbu G Lenardo Michael J MJ

Science (New York, N.Y.) 20130701 6142

The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg(2+)) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg(2+) causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in M ...[more]

PMID: 23846901

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Dataset Information

Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

Publications

Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

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