A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
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ABSTRACT:
SUBMITTER: Lee MK
PROVIDER: S-EPMC3894927 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
Lee Mi-Kyung MK Bottini Angel A Kim Meehyein M Bardaro Michael F MF Zhang Ziming Z Pellecchia Maurizio M Choi Byong-Seok BS Varani Gabriele G
Chemical communications (Cambridge, England) 20131118 3
Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses. ...[more]
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