Ontology highlight
ABSTRACT:
SUBMITTER: Shen Y
PROVIDER: S-EPMC3895402 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Shen Yue Y Giardino Torchia Maria Letizia ML Lawson Gregory W GW Karp Christopher L CL Ashwell Jonathan D JD Mazmanian Sarkis K SK
Cell host & microbe 20120920 4
Commensal bacteria impact host health and immunity through various mechanisms, including the production of immunomodulatory molecules. Bacteroides fragilis produces a capsular polysaccharide (PSA), which induces regulatory T cells and mucosal tolerance. However, unlike pathogens, which employ secretion systems, the mechanisms by which commensal bacteria deliver molecules to the host remain unknown. We reveal that Bacteroides fragilis releases PSA in outer membrane vesicles (OMVs) that induce imm ...[more]