Ontology highlight
ABSTRACT:
SUBMITTER: Chijioke O
PROVIDER: S-EPMC3895765 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Cell reports 20131219 6
Primary infection with the human oncogenic Epstein-Barr virus (EBV) can result in infectious mononucleosis (IM), a self-limiting disease caused by massive lymphocyte expansion that predisposes for the development of distinct EBV-associated lymphomas. Why some individuals experience this symptomatic primary EBV infection, whereas the majority acquires the virus asymptomatically, remains unclear. Using a mouse model with reconstituted human immune system components, we show that depletion of human ...[more]