Ontology highlight
ABSTRACT:
SUBMITTER: Gelev V
PROVIDER: S-EPMC3895905 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20140120
Experimental and bioinformatic studies of transcription initiation by RNA polymerase II (RNAP2) have revealed a mechanism of RNAP2 transcription initiation less uniform across gene promoters than initially thought. However, the general transcription factor TFIIB is presumed to be universally required for RNAP2 transcription initiation. Based on bioinformatic analysis of data and effects of TFIIB knockdown in primary and transformed cell lines on cellular functionality and global gene expression, ...[more]