Ontology highlight
ABSTRACT:
SUBMITTER: Zhi X
PROVIDER: S-EPMC3896210 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zhi Xiaoyong X Zhou X Edward XE He Yuanzheng Y Zechner Christoph C Suino-Powell Kelly M KM Kliewer Steven A SA Melcher Karsten K Mangelsdorf David J DJ Xu H Eric HE
Proceedings of the National Academy of Sciences of the United States of America 20131230 2
Small heterodimer partner (SHP) is an orphan nuclear receptor that functions as a transcriptional repressor to regulate bile acid and cholesterol homeostasis. Although the precise mechanism whereby SHP represses transcription is not known, E1A-like inhibitor of differentiation (EID1) was isolated as a SHP-interacting protein and implicated in SHP repression. Here we present the crystal structure of SHP in complex with EID1, which reveals an unexpected EID1-binding site on SHP. Unlike the classic ...[more]