Ontology highlight
ABSTRACT:
SUBMITTER: Colpitts SL
PROVIDER: S-EPMC3896262 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Colpitts Sara L SL Stonier Spencer W SW Stoklasek Thomas A TA Root Sierra H SH Aguila Hector Leonardo HL Schluns Kimberly S KS Lefrançois Leo L
Journal of immunology (Baltimore, Md. : 1950) 20130821 6
Dendritic cells (DCs) are the most commonly studied source of the cytokine IL-15. Using an IL-15 reporter transgenic mouse, we have recently shown previously unappreciated differences in the levels of IL-15 expressed by subsets of conventional DCs (CD8⁺ and CD8⁻). In this study, we show that IL-15 promoter activity was differentially regulated in subsets of hematopoietically derived cells with IL-15 expression largely limited to myeloid lineages. In contrast, mature cells of the lymphoid lineage ...[more]