Ontology highlight
ABSTRACT:
SUBMITTER: Berti M
PROVIDER: S-EPMC3897332 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Berti Matteo M Ray Chaudhuri Arnab A Thangavel Saravanabhavan S Gomathinayagam Shivasankari S Kenig Sasa S Vujanovic Marko M Odreman Federico F Glatter Timo T Graziano Simona S Mendoza-Maldonado Ramiro R Marino Francesca F Lucic Bojana B Biasin Valentina V Gstaiger Matthias M Aebersold Ruedi R Sidorova Julia M JM Monnat Raymond J RJ Lopes Massimo M Vindigni Alessandro A
Nature structural & molecular biology 20130210 3
Topoisomerase I (TOP1) inhibitors are an important class of anticancer drugs. The cytotoxicity of TOP1 inhibitors can be modulated by replication fork reversal through a process that requires poly(ADP-ribose) polymerase (PARP) activity. Whether regressed forks can efficiently restart and what factors are required to restart fork progression after fork reversal are still unknown. We have combined biochemical and EM approaches with single-molecule DNA fiber analysis to identify a key role for huma ...[more]