Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3897378 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Liu Yun Y Cao Lan L Li Zhiqiang Z Zhou Daizhan D Liu Wanqing W Shen Qin Q Wu Yanting Y Zhang Dan D Hu Xun X Wang Ting T Ye Junyi J Weng Xiaoling X Zhang Hong H Zhang Di D Zhang Zhou Z Liu Fatao F He Lin L Shi Yongyong Y
PloS one 20140121 1
Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related diseases. We performed genome-wide association studies of mean LTL in 2632 individuals,with a two-stage replication in 3917 individuals from Chinese populations. To further validate our findings, we get the results of 696 samples from a cohort of European ancestry. We identified two loci associated with LTL that map in telomerase reverse transcriptase (TERT; rs2736100, P = 1.93×10(-5)) on chromosome 5p15.33 and n ...[more]