Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.
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ABSTRACT:
SUBMITTER: Hsiao EY
PROVIDER: S-EPMC3897394 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.
Hsiao Elaine Y EY McBride Sara W SW Hsien Sophia S Sharon Gil G Hyde Embriette R ER McCue Tyler T Codelli Julian A JA Chow Janet J Reisman Sarah E SE Petrosino Joseph F JF Patterson Paul H PH Mazmanian Sarkis K SK
Cell 20131205 7
Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities. We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD. Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ...[more]
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