Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3897473 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Li Jiong J Chen Xiaohong X Ding Xiangming X Cheng Yingduan Y Zhao Bin B Lai Zhi-Chun ZC Al Hezaimi Khalid K Hakem Razqallah R Guan Kun-Liang KL Wang Cun-Yu CY
Cell reports 20131219 6
Abnormal activation of Wnt/β-catenin-mediated transcription is associated with a variety of human cancers. Here, we report that LATS2 inhibits oncogenic Wnt/β-catenin-mediated transcription by disrupting the β-catenin/BCL9 interaction. LATS2 directly interacts with β-catenin and is present on Wnt target gene promoters. Mechanistically, LATS2 inhibits the interaction between BCL9 and β-catenin and subsequent recruitment of BCL9, independent of LATS2 kinase activity. LATS2 is downregulated and inv ...[more]