Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma.
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ABSTRACT:
SUBMITTER: Zhang ZC
PROVIDER: S-EPMC3897649 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma.
Zhang Zi-Chen ZC Li Yang-Yang YY Wang Hai-Yun HY Fu Sha S Wang Xiao-Pai XP Zeng Mu-Sheng MS Zeng Yi-Xin YX Shao Jian-Yong JY
PloS one 20140121 1
MicroRNA-214 (MiR-214) is aberrantly expressed in several human tumors such as ovarian cancer and breast cancer. However, the role of miR-214 in nasopharyngeal carcinoma (NPC) is still unknown. In this study, we report that miR-214 was overexpressed in NPC cell lines and tissues. Silencing of miR-214 by LNA-antimiR-214 in NPC cells resulted in promoting apoptosis and suppressing cell proliferation in vitro, and suppressed tumor growth in nude mice in vivo. Luciferase reporter assay was performed ...[more]
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