Ontology highlight
ABSTRACT:
SUBMITTER: Millien VO
PROVIDER: S-EPMC3898200 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Millien Valentine Ongeri VO Lu Wen W Shaw Joanne J Yuan Xiaoyi X Mak Garbo G Roberts Luz L Song Li-Zhen LZ Knight J Morgan JM Creighton Chad J CJ Luong Amber A Kheradmand Farrah F Corry David B DB
Science (New York, N.Y.) 20130801 6147
Proteinases and the innate immune receptor Toll-like receptor 4 (TLR4) are essential for expression of allergic inflammation and diseases such as asthma. A mechanism that links these inflammatory mediators is essential for explaining the fundamental basis of allergic disease but has been elusive. Here, we demonstrate that TLR4 is activated by airway proteinase activity to initiate both allergic airway disease and antifungal immunity. These outcomes were induced by proteinase cleavage of the clot ...[more]