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ABSTRACT: Objective
To estimate the contributions of biological aging, historical trends, and birth cohort effects on trends in pre-eclampsia in the United States.Design
Population based retrospective study.Setting
National hospital discharge survey datasets, 1980-2010, United States.Participants
120 million women admitted to hospital for delivery.Main outcome measures
Temporal changes in rates of mild and severe pre-eclampsia in relation to maternal age, year of delivery, and birth cohorts. Poisson regression as well as multilevel age-period-cohort models with adjustment for obesity and smoking were incorporated.Results
The rate of pre-eclampsia was 3.4%. The age-period-cohort analysis showed a strong age effect, with women at the extremes of maternal age having the greatest risk of pre-eclampsia. In comparison with women delivering in 1980, those delivering in 2003 were at 6.7-fold (95% confidence interval 5.6-fold to 8.0-fold) increased risk of severe pre-eclampsia. Period effects declined after 2003. Trends for severe pre-eclampsia also showed a modest birth cohort effect, with women born in the 1970s at increased risk. Compared with women born in 1955, the risk ratio for women born in 1970 was 1.2 (95% confidence interval 1.1 to 1.3). Similar patterns were also evident for mild pre-eclampsia, although attenuated. Changes in the population prevalence of obesity and smoking were associated with period and cohort trends in pre-eclampsia but did not explain the trends.Conclusions
Rates of severe pre-eclampsia have been increasing in the United States and age-period-cohort effects all contribute to these trends. Although smoking and obesity have driven these trends, changes in the diagnostic criteria may have also contributed to the age-period-cohort effects. Health consequences of rising obesity rates in the United States underscore that efforts to reduce obesity may be beneficial to maternal and perinatal health.
SUBMITTER: Ananth CV
PROVIDER: S-EPMC3898425 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Ananth Cande V CV Keyes Katherine M KM Wapner Ronald J RJ
BMJ (Clinical research ed.) 20131107
<h4>Objective</h4>To estimate the contributions of biological aging, historical trends, and birth cohort effects on trends in pre-eclampsia in the United States.<h4>Design</h4>Population based retrospective study.<h4>Setting</h4>National hospital discharge survey datasets, 1980-2010, United States.<h4>Participants</h4>120 million women admitted to hospital for delivery.<h4>Main outcome measures</h4>Temporal changes in rates of mild and severe pre-eclampsia in relation to maternal age, year of de ...[more]