Ontology highlight
ABSTRACT:
SUBMITTER: Tchigvintsev A
PROVIDER: S-EPMC3899018 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Chemistry & biology 20131024 11
Maf (for multicopy associated filamentation) proteins represent a large family of conserved proteins implicated in cell division arrest but whose biochemical activity remains unknown. Here, we show that the prokaryotic and eukaryotic Maf proteins exhibit nucleotide pyrophosphatase activity against 5-methyl-UTP, pseudo-UTP, 5-methyl-CTP, and 7-methyl-GTP, which represent the most abundant modified bases in all organisms, as well as against canonical nucleotides dTTP, UTP, and CTP. Overexpression ...[more]