Ontology highlight
ABSTRACT:
SUBMITTER: Gieseck RL
PROVIDER: S-EPMC3899231 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gieseck Richard L RL Hannan Nicholas R F NR Bort Roque R Hanley Neil A NA Drake Rosemary A L RA Cameron Grant W W GW Wynn Thomas A TA Vallier Ludovic L
PloS one 20140122 1
Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in applications ranging from therapeutic cell infusions to in vitro toxicology studies. However, current differentiation protocols and culture methods produce cells with reduced functionality and fetal-like properties compared to adult hepatocytes. We report a culture method for the maturation of IPSC-Heps using 3-Dimensional (3D) collagen matrices co ...[more]