Does reduced creatine synthesis protect against statin myopathy?
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ABSTRACT:
SUBMITTER: Ballard KD
PROVIDER: S-EPMC3899594 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Does reduced creatine synthesis protect against statin myopathy?
Ballard Kevin D KD Thompson Paul D PD
Cell metabolism 20131201 6
Statins, widely used to lower cholesterol levels, cause myopathy in some patients. Mangravite et al. (2013) show that a single nucleotide polymorphism decreasing expression of glycine amidinotransferase (GATM), the enzyme regulating creatine biosynthesis, is associated with reduced statin myopathy. Whether reduced creatine production protects against statin myopathy remains to be determined. ...[more]
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Project description:We performed a genome-wide association study in pooled DNA samples from patients with severe statin myopathy and persistent symptoms post-therapy versus pooled DNAs from an age-adjusted statin-tolerant group.
2010-07-09 | GSE17574 | GEO
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Project description:Genetic Susceptibility to Statin-Induced Myopathy
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