Ontology highlight
ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC3899844 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chen Qingxia Q Zeng Donglin D Ibrahim Joseph G JG Akacha Mouna M Schmidli Heinz H
Biometrika 20130101 2
In the analysis of multivariate event times, frailty models assuming time-independent regression coefficients are often considered, mainly due to their mathematical convenience. In practice, regression coefficients are often time dependent and the temporal effects are of clinical interest. Motivated by a phase III clinical trial in multiple sclerosis, we develop a semiparametric frailty modelling approach to estimate time-varying effects for overdispersed recurrent events data with treatment swi ...[more]