Ontology highlight
ABSTRACT:
SUBMITTER: Slaughter BD
PROVIDER: S-EPMC3900288 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Slaughter Brian D BD Unruh Jay R JR Das Arupratan A Smith Sarah E SE Rubinstein Boris B Li Rong R
Nature communications 20130101
Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar plasma membrane, with sites of exocytosis correlating with microdomains of higher concentration and slower diffusion of Cdc42 compared with surrounding regions. Numerical simulations u ...[more]