Ontology highlight
ABSTRACT:
SUBMITTER: Kundu P
PROVIDER: S-EPMC3900641 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Kundu Parag P Ling Teo Wei TW Korecka Agata A Li Yinghui Y D'Arienzo Rossana R Bunte Ralph M RM Berger Thorsten T Arulampalam Velmurugesan V Chambon Pierre P Mak Tak Wah TW Wahli Walter W Pettersson Sven S
PLoS pathogens 20140123 1
To be able to colonize its host, invading Salmonella enterica serovar Typhimurium must disrupt and severely affect host-microbiome homeostasis. Here we report that S. Typhimurium induces acute infectious colitis by inhibiting peroxisome proliferator-activated receptor gamma (PPARγ) expression in intestinal epithelial cells. Interestingly, this PPARγ down-regulation by S. Typhimurium is independent of TLR-4 signaling but triggers a marked elevation of host innate immune response genes, including ...[more]