Sugar for the brain: the role of glucose in physiological and pathological brain function.
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ABSTRACT:
SUBMITTER: Mergenthaler P
PROVIDER: S-EPMC3900881 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Sugar for the brain: the role of glucose in physiological and pathological brain function.
Mergenthaler Philipp P Lindauer Ute U Dienel Gerald A GA Meisel Andreas A
Trends in neurosciences 20130820 10
The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. We synthesize these fi ...[more]
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