The role of autophagy in Crohn's disease.
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ABSTRACT:
SUBMITTER: Henderson P
PROVIDER: S-EPMC3901108 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide association scans have recently identified autophagy genes as conferring susceptibility to Crohn's disease (CD), one of the chronic inflammatory bowel diseases, with evidence suggesting that CD arises from a defective innate immune response to enteric bact ...[more]
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