Ontology highlight
ABSTRACT:
SUBMITTER: Wagh B
PROVIDER: S-EPMC3901159 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Wagh Bharat B Paul Tapas T Debrosse Charles C Klepacki Dorota D Small Meagan C MC Mackerell Alexander D AD Andrade Rodrigo B RB
ACS medicinal chemistry letters 20131101 11
Antibiotic-resistant bacteria are emerging at an alarming rate in both hospital and community settings. Motivated by this issue, we have prepared desmethyl (i.e., replacing methyl groups with hydrogens) analogues of third-generation macrolide drugs telithromycin (TEL, <b>2</b>) and cethromycin (CET, <b>6</b>), both of which are semi-synthetic derivatives of flagship macrolide antibiotic erythromycin (<b>1</b>). Herein, we report the total synthesis, molecular modeling, and biological evaluation ...[more]