Ensemble kinetic modeling of metabolic networks from dynamic metabolic profiles.
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ABSTRACT:
SUBMITTER: Jia G
PROVIDER: S-EPMC3901226 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Ensemble kinetic modeling of metabolic networks from dynamic metabolic profiles.
Jia Gengjie G Jia Gengjie G Stephanopoulos Gregory G Gunawan Rudiyanto R
Metabolites 20121112 4
Kinetic modeling of metabolic pathways has important applications in metabolic engineering, but significant challenges still remain. The difficulties faced vary from finding best-fit parameters in a highly multidimensional search space to incomplete parameter identifiability. To meet some of these challenges, an ensemble modeling method is developed for characterizing a subset of kinetic parameters that give statistically equivalent goodness-of-fit to time series concentration data. The method i ...[more]
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