Ontology highlight
ABSTRACT:
SUBMITTER: Prior C
PROVIDER: S-EPMC3901669 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Prior Celia C Perez-Gracia Jose Luis JL Garcia-Donas Jesus J Rodriguez-Antona Cristina C Guruceaga Elizabeth E Esteban Emilio E Suarez Cristina C Castellano Daniel D del Alba Aránzazu González AG Lozano Maria Dolores MD Carles Joan J Climent Miguel Angel MA Arranz Jose Angel JA Gallardo Enrique E Puente Javier J Bellmunt Joaquim J Gurpide Alfonso A Lopez-Picazo Jose Maria JM Hernandez Alvaro Gonzalez AG Mellado Begoña B Martínez Esther E Moreno Fernando F Font Albert A Calvo Alfonso A
PloS one 20140124 1
<h4>Purpose</h4>To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate in vitro their mechanism of action in sunitinib resistance.<h4>Methods</h4>We screened 673 microRNAs using TaqMan Low-density-Arrays (TLDAs) in tumors from MRCC patients with extreme phenotypes of marked efficacy and resistance to sunitinib, selected from an identification cohort (n = 41). The most relevant differentially expressed microRNAs were s ...[more]