Uridine prevents fenofibrate-induced fatty liver.
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ABSTRACT:
SUBMITTER: Le TT
PROVIDER: S-EPMC3901748 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Uridine prevents fenofibrate-induced fatty liver.
Le Thuc T TT Urasaki Yasuyo Y Pizzorno Giuseppe G
PloS one 20140124 1
Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are examined. At a daily dosage of 400 mg/kg, fenofibrate treatment causes reduction of liver NAD(+)/NADH ratio, induces hyper-acetylation of peroxisomal bifunctional enzyme (ECHD) and acyl-CoA oxidase 1 (ACOX1), and induces excessive accumulation of ...[more]
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