Ontology highlight
ABSTRACT:
SUBMITTER: Kumar SK
PROVIDER: S-EPMC3901994 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Kumar Shaji K SK Lacy Martha Q MQ Hayman Suzanne R SR Stewart Keith K Buadi Francis K FK Allred Jacob J Laumann Kristina K Greipp Philip R PR Lust John A JA Gertz Morie A MA Zeldenrust Steven R SR Bergsagel P Leif PL Reeder Craig B CB Witzig Thomas E TE Fonseca Rafael R Russell Stephen J SJ Mikhael Joseph R JR Dingli David D Rajkumar S Vincent SV Dispenzieri Angela A
American journal of hematology 20110531 8
The combination of lenalidomide and low-dose dexamethasone is an effective treatment for multiple myeloma (MM). Addition of alkylating agents to lenalidomide or thalidomide results in increased response rates and deeper responses. We designed this trial to study the combination of cyclophosphamide, lenalidomide, and dexamethasone (CRd) as initial therapy for MM. Fifty-three patients with previously untreated symptomatic MM was enrolled. Patients received 4-week treatment cycles consisting of len ...[more]